Vol. 2, Issue 1, Part A (2025)

Phytomedicine, the use of plant-based compounds for therapeutic purposes, has attracted significant attention due to its potential health benefits. Among the myriad of bioactive plant-derived compounds, polyphenols, alkaloids, and terpenoids stand out for their diverse pharmacological properties. Despite their promising therapeutic potential, these compounds often suffer from poor bioavailability when administered in their natural form. This limitation is primarily due to their low solubility, instability, and rapid metabolism. Nanotechnology has emerged as a transformative strategy to overcome these barriers and enhance the bioavailability of phytochemicals. This paper explores the role of nanotechnology-based delivery systems in improving the pharmacokinetics of polyphenols, alkaloids, and terpenoids with a focus on the various nanocarriers and their mechanisms of action. Furthermore, the paper discusses the challenges associated with nanotechnology-enabled delivery systems and their future prospects in the realm of phytomedicine.