Vol. 2, Issue 1, Part A (2025)

Curcumin, the principal polyphenolic compound derived from Curcuma longa, and resveratrol, a stilbene predominantly found in grapes and peanuts, have gained extensive attention for their multifaceted therapeutic properties. Both compounds exhibit potent anti-inflammatory and antioxidant effects, making them valuable candidates in the prevention and management of chronic diseases such as cardiovascular disorders, metabolic syndromes, neurodegeneration, and cancer. Despite their pharmacological promise, limitations such as poor bioavailability, instability, and rapid metabolism hinder their clinical translation. Recent advances in phytopharmacology have demonstrated that curcumin and resveratrol, when administered in combination, may exert synergistic effects that surpass their individual efficacy by targeting complementary signaling pathways, including NF-κB, Nrf2, SIRT1, and MAPKs. This comparative evaluation aims to integrate preclinical and clinical evidence to elucidate the mechanistic basis of their synergistic action in inflammation and oxidative stress management.
The present study employs a comparative framework, utilizing biochemical assays, computational modeling, and systematic literature synthesis, to assess the pharmacokinetics, molecular targets, and therapeutic outcomes of curcumin and resveratrol individually and in combination. Results indicate that the synergistic pairing enhances cellular antioxidant defenses, downregulates pro-inflammatory cytokines, and modulates redox-sensitive transcription factors more effectively than monotherapy. These findings underscore the translational potential of dual phytochemical therapy in chronic inflammatory and oxidative stress-related diseases. Future research should focus on optimizing delivery systems, such as nanocarriers and liposomal encapsulation, to overcome bioavailability challenges and facilitate clinical application. This paper contributes to the evolving discourse on evidence-based phytopharmacology and positions curcumin-resveratrol synergy as a promising frontier in integrative medicine.