Vol. 1, Issue 1, Part A (2024)

Bacopa monnieri (L.) Wettst., commonly referred to as Brahmi, is a traditional Ayurvedic herb widely used for its cognitive-enhancing properties. Emerging pharmacological evidence supports its use in improving memory, attention, and learning, primarily attributed to its saponin constituents, particularly bacosides A and B. These bioactive compounds exert neuroprotective effects through mechanisms such as antioxidant activity, modulation of cholinergic signaling, reduction of β-amyloid accumulation, and promotion of neurogenesis. This review consolidates findings from preclinical and clinical studies to assess the therapeutic potential of Bacopa monnieri in cognitive disorders, including mild cognitive impairment, Alzheimer's disease, and stress-induced memory decline. The paper also addresses current limitations in bioavailability, standardization, and clinical trial design while identifying areas for future research and therapeutic integration.