Vol. 1, Issue 1, Part A (2024)

Hypericum perforatum L., commonly known as St. John's Wort, has emerged as one of the most extensively researched herbal medicines for its diverse pharmacological activities, including antidepressant, antiviral, anti-inflammatory, and wound healing effects. This review presents a comprehensive overview of the phytopharmacological properties of H. perforatum, along with comparative insights into other plant-derived agents with similar bioactive potentials. We analyzed peer-reviewed literature focusing on plant metabolites, extraction methods, experimental models, clinical studies, and pharmacodynamic mechanisms associated with H. perforatum and other botanicals such as Withania somnifera, Curcuma longa, and Ginkgo biloba. The materials were selected through a structured literature search, and relevant data were categorized and interpreted. Results indicate that H. perforatum exhibits significant effects in managing mild to moderate depression, largely through hyperforin- and hypericin-mediated neurotransmitter modulation. Other plants demonstrated synergistic or complementary effects, especially in neuroprotective, anti-inflammatory, and antioxidant pathways. Tables included in this review summarize clinical trials, phytoconstituent profiles, and pharmacological outcomes. The discussion critically evaluates the efficacy, safety profiles, and regulatory challenges associated with phytomedicine integration into clinical practice. Based on current evidence, H. perforatum and select botanicals offer promising adjunctive or alternative treatment strategies, although caution must be exercised in terms of drug interactions and standardization issues. Future research should focus on bioavailability, formulation enhancement, and multicentric clinical trials to validate therapeutic claims.